Status:

COMPLETED

Multiple Dose Study to Evaluate the Safety of Multiple Doses of Denosumab 120 mg in Adults With Severe Chronic Kidney Disease (CKD) and CKD on Dialysis

Lead Sponsor:

Amgen

Conditions:

Renal Impairment

Eligibility:

All Genders

18+ years

Phase:

PHASE1

Brief Summary

The primary objective was to evaluate the incidence of clinically significant hypocalcemia following multiple 120 mg subcutaneous doses of denosumab in patients with severe chronic kidney disease (CKD...

Eligibility Criteria

Inclusion

  • Subjects at least 18 years old with severe CKD (defined as creatinine clearance \< 30 mL/min at both screening assessments) and CKD requiring hemodialysis
  • Additional inclusion criteria apply

Exclusion

  • Subjects must have calcium, phosphate, and magnesium levels appropriate for their condition and must not have other uncontrolled co-morbidities.
  • Additional exclusion criteria apply

Key Trial Info

Start Date :

November 1 2011

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

March 1 2013

Estimated Enrollment :

32 Patients enrolled

Trial Details

Trial ID

NCT01464931

Start Date

November 1 2011

End Date

March 1 2013

Last Update

February 19 2016

Active Locations (7)

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Page 1 of 2 (7 locations)

1

Research Site

Tempe, Arizona, United States, 85284

2

Research Site

Denver, Colorado, United States, 80230

3

Research Site

Pembroke Pines, Florida, United States, 33028

4

Research Site

Meridian, Idaho, United States, 83642