Status:
COMPLETED
The Effect of Citrasate Dialysate on Heparin Dose in Hemodialysis
Lead Sponsor:
University of Calgary
Conditions:
Chronic Kidney Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
An alternative to systemic heparin anticoagulation for HD is citrate dialysate (CD). CD contains a small amount of citric acid rather than acetic acid as the acidifying agent. The use of citrasate may...
Detailed Description
The investigators will perform a randomized, double-blind, two-period crossover trial in chronic HD patients to compare the effect of citrasate dialysate (CD) and usual acetic-acid based dialysate (AD...
Eligibility Criteria
Inclusion
- chronic stable HD patients ≥ 18 years
- on HD at least three times per week for at least 3 months
Exclusion
- contraindication to heparin
- currently using heparin-free HD
- known clotting disorder
- on warfarin therapy
- dialyzing with a dysfunctional central venous catheter (blood flow rates consistently less than 300mL/min and/or frequent use of thrombolytic)
- history of vascular access dysfunction
- planned vascular access conversion or procedure during the study period
- use of high calcium dialysate
- active medical issue requiring hospitalization
- planned kidney transplant during the study period
- planned conversion of dialysis modality (peritoneal dialysis, nocturnal dialysis) during the study period
- unable to provide informed consent
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01466959
Start Date
November 1 2011
End Date
January 1 2013
Last Update
March 26 2013
Active Locations (1)
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1
University of Calgary
Calgary, Alberta, Canada, T2N 2T9