Status:
COMPLETED
Glutamine and Insulin Sensitivity in Type I Diabetes
Lead Sponsor:
Nemours Children's Clinic
Collaborating Sponsors:
Thrasher Research Fund
Conditions:
Type I Diabetes Mellitus
Eligibility:
All Genders
13-19 years
Phase:
NA
Brief Summary
Insulin is crucial to help the body metabolize ('burn') sugar (glucose). Even though juvenile (type 1) diabetes (T1D) is primarily due to the lack of insulin, patients with T1D tend to become less sen...
Eligibility Criteria
Inclusion
- Type I diabetes diagnosed for \> 12 months.
- Minimal weight of 40 kg
- Tanner stage IV or beyond
- All insulin programs, including intermediate/short acting insulins, Lantus/Detemir and short acting insulin or insulin pump therapy.
- HbA1C between 7.5 and 10%
- BMI between 10th to 85th percentile
- Patients on stable thyroid replacement therapy will be allowed to participate.
Exclusion
- Celiac disease (any patient with history of positive serology or consuming a gluten-free diet)
- Cystic Fibrosis
- Chronic steroid therapy
- Chronic medications that may interfere with glucose metabolism or liver function
- History of mental retardation
- Presence of diabetic complications
- Positive pregnancy test
- Presence of significant anemia (Hb\<11 g/dL)
- Presence of intercurrent infection
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT01467063
Start Date
October 1 2011
End Date
July 1 2013
Last Update
July 14 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Nemours Children's Clinic
Jacksonville, Florida, United States, 32207