Status:
COMPLETED
The Effect of Dietary Fat Load and Physical Exercise on the Flexibility and Partitioning of Ectopic Lipids.
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Collaborating Sponsors:
Swiss National Science Foundation
Conditions:
Ectopic Lipids
Insulin Sensitivity
Eligibility:
All Genders
18-80 years
Brief Summary
This study aims at assessing the effect of standardized dietary fat load and short-term aerobic exercise on systemic lipolysis, flexibility and partitioning of ectopic fat stores (intramyocellular = I...
Detailed Description
Background Obesity, in particular visceral obesity, is associated with impaired insulin action on target tissues (insulin resistance or metabolic syndrome) that, in turn, is related to an increased r...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Male and female patients \>18 years old
- Capable to exercise for 120 minutes on a treadmill
- Willingness to participate in the study and to give written consent.
- Normal ECG during ergometry
- Specific for Athletes: VO2max\> 50 ml/kg/min
- Specific for GHD patients: no GH substitution in the last 6 months
- Specific for sedentary controls: Matched the GHD patients for age, gender, BMI and waist
- Exclusion Criteria
- Abnormal liver or renal function
- Active neoplasia
- Severe cardiovascular disease (unstable coronary artery disease, heart failure NYHA III-IV)
- Haemophilia
- Inability to exercise
- Contraindications to exposure to a 3 T magnetic field
- Abnormal ECG during ergometry
- Women in childbearing age unless on a continuous contraceptive therapy or surgically sterilized
- Depression, psychosis and other severe personality disorders
- Pregnant women
- Excessive alcohol consumption (\>60g/d) or drug abuse
Exclusion
Key Trial Info
Start Date :
August 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2014
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01467193
Start Date
August 1 2011
End Date
May 1 2014
Last Update
October 9 2018
Active Locations (1)
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1
Department of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Bern
Bern, Switzerland, 3010