Status:
UNKNOWN
Sequential Left Prefrontal Repetitive Transcranial Magnetic Stimulation, With High Frequency, for Treatment-Resistant Depression
Lead Sponsor:
Tehran University of Medical Sciences
Conditions:
Treatment-Resistant Depression Disease
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Sequential left prefrontal Repetitive Transcranial Magnetic Stimulation (rTMS), with high frequency, for Treatment-Resistant Depression have been shown to have antidepressant effects. but doubts remai...
Detailed Description
Design: Prospective, randomized, active sham-controlled (1:1 randomization), duration-adaptive design with 3 weeks of daily weekday treatment (fixed-dose phase) followed by continued blinded treatmen...
Eligibility Criteria
Inclusion
- DSM-IV diagnosis of major depression
- Resistance to treatment as defined by the insufficient clinical benefit to at least one adequate medication trials
Exclusion
- Other current Axis I disorders (except simple phobia and nicotine addiction)
- Personal or close family history of seizure disorder
- Ferromagnetic material in body or close to head
- Neurologic disorder
- Pregnancy
- Taking medications known to lower seizure threshold (eg, theophylline)
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2012
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01469325
Start Date
November 1 2011
End Date
February 1 2012
Last Update
November 22 2011
Active Locations (1)
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1
Iranian National Center for Addiction Studies
Tehran, Tehran Province, Iran