Status:
COMPLETED
Effects of Cardiopulmonary Bypass (CPB)-Leukocyte Filtration on Interleukins Serum Levels and Pulmonary Function
Lead Sponsor:
University of Sao Paulo
Collaborating Sponsors:
InCor Heart Institute
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conditions:
Systemic Inflammatory Response Syndrome (SIRS)
Leukocyte Disorders
Eligibility:
All Genders
Up to 70 years
Phase:
NA
Brief Summary
To test the hypothesis that leukocyte filtering during cardiopulmonary bypass (CPB) might reduce the inflammatory response and protect the lungs against the acute injury
Detailed Description
BACKGROUND AND OBJECTIVES: The extension of the systemic inflammatory response observed after cardiopulmonary bypass (CPB) in cardiac surgery is associated to postoperative pulmonary dysfunction degre...
Eligibility Criteria
Inclusion
- Patients undergoing coronary artery bypass grafting (CABG), having their physical state classified as PII and PIII, according to the American Society of Anesthesiologists (ASA). Surgical risk was stratified according to Parsonnet criteria, and only patients considered low to moderate risk were admitted.
Exclusion
- Subjects older than 70 years
- Body mass index (BMI) over 35 kg/m2
- Congestive heart failure (CHF) greater than class III (NYHA)
- Left ventricle ejection fraction less than 40%
- Submitted to recent surgery
- creatinine ≥ 1.4 mg / dL or in use of oral anticoagulants were excluded
Key Trial Info
Start Date :
February 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT01469676
Start Date
February 1 2007
End Date
October 1 2010
Last Update
November 10 2011
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