Status:
COMPLETED
Biomarkers in Autosomal Dominant Cerebellar Ataxia
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Spinocerebellar Ataxia Type 1
Spinocerebellar Ataxia Type 2
Eligibility:
All Genders
18+ years
Brief Summary
Autosomal dominant cerebellar ataxias (ADCA) are a group of neurodegenerative disorders that are clinically and genetically various. BIOSCA study aims to identify markers of the metabolism (energy pro...
Detailed Description
Rational. Autosomal dominant cerebellar ataxias (ADCA) are a clinically heterogeneous group of neurodegenerative disorders caused by unstable CAG repeat expansions encoding polyglutamine tracts. ADCA ...
Eligibility Criteria
Inclusion
- Inclusion criteria :
- More than 18 years of age
- Ability to tolerate MRI
- Positive genetic test to SCA1, 2, 3 or 7
- Coverage by social insurance
- Written informed consent must be obtained from the subject
- Exclusion criteria :
- Less than 18 years of age
- Concomitant significant neurological disorder
- Unsuitability for MRI, e.g. claustrophobia, metal implants
- History of significant head injury
- Unability to receive an informed explanation about the protocol
- Unability to complete the protocol
- Non coverage by social insurance
- No written informed consent obtained
Exclusion
Key Trial Info
Start Date :
November 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT01470729
Start Date
November 1 2011
End Date
December 1 2015
Last Update
September 6 2019
Active Locations (1)
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1
Groupe Hospitalier Pitié Salpêtrière
Paris, France, 75013