Status:
UNKNOWN
Fibre Specific Signalling in the Locomotor Myopathy of Chronic Obstructive Pulmonary Disease
Lead Sponsor:
Royal Brompton & Harefield NHS Foundation Trust
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
40-90 years
Brief Summary
Skeletal muscle is composed of two fibre types which are intertwined. Skeletal muscle weakness, particularly of the walking muscles, is an important complication of Chronic Obstructive Pulmonary Disea...
Eligibility Criteria
Inclusion
- Male or female aged 40 - 90 years inclusive.
- A clinical diagnosis of COPD based on spirometry (FEV1/FVC ratio \< 70% on entry to the study with FEV1 \< 80% predicted)
Exclusion
- History or current diagnosis of alpha 1-anti-trypsin deficiency, asthma, lung cancer, bronchiectasis or other significant respiratory disease (including treated TB in the past 10 years)
- Contraindication to biopsy for research purpose (e.g. use of anticoagulant in the 1 week prior to biopsy)
- Joint or neurological disease which on its own would preclude exercise
Key Trial Info
Start Date :
December 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2013
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT01471587
Start Date
December 1 2011
End Date
October 1 2013
Last Update
December 2 2011
Active Locations (1)
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1
Royal Brompton Hospital
London, UK, United Kingdom, SE8 4DY