Status:
UNKNOWN
Adiponectin and Circulating Macrophage Phenotypes in Non-alcoholic Fatty Liver Disease (NAFLD)
Lead Sponsor:
Gulhane School of Medicine
Conditions:
Non-alcoholic Fatty Liver Disease
Eligibility:
MALE
20-60 years
Brief Summary
In peripheral blood; monocytes and macrophages are found in two phenotype; proinflammatory M1 and anti-inflammatory M2 phenotypes. M2 form is converted (or polarized) to M1 phenotype in various metabo...
Detailed Description
In peripheral blood; monocytes and macrophages are found in two phenotype; proinflammatory M1 and anti-inflammatory M2 phenotypes. M2 form is converted (or polarized) to M1 phenotype in various metab...
Eligibility Criteria
Inclusion
- Persistently (at least 6 months) elevated aminotransferases
- Ultrasonographic presence of bright liver without any other liver or biliary tract disease
- Liver histology compatible with a diagnosis of NASH or SS
Exclusion
- A history of alcohol consumption \>40 g/wk, as assessed by a detailed interview extended to family members
- Morbid obesity \[body mass index (BMI) ≥40 kg/m2\], hypertension
- Positive blood markers of viral, autoimmune, or celiac disease
- Abnormal copper metabolism or thyroid function tests
- A diagnosis of T2DM and systemic arterial hypertension
- Total cholesterol (TC) ≥250 mg/dL, triglycerides (TG) ≥400 mg/dL, exposure to occupational hepatotoxins or drugs known to affect glucose and lipid metabolism
Key Trial Info
Start Date :
December 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2013
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT01472120
Start Date
December 1 2011
End Date
January 1 2013
Last Update
November 16 2011
Active Locations (1)
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1
Gastroenterology Department, Gulhane School of Medicine
Ankara, Turkey (Türkiye), 06018