Status:
COMPLETED
Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure
Lead Sponsor:
University of California, San Diego
Conditions:
Prehypertension
Gout
Eligibility:
All Genders
18-50 years
Phase:
PHASE4
Brief Summary
High normal blood pressure, also called prehypertension, is a significant problem. High uric acid in the blood, the same thing that causes gout, may cause higher blood pressures. The investigators pla...
Eligibility Criteria
Inclusion
- Prehypertensive male and female subjects with SBP =120-140 mmHg or DBP =80-90 mmHg (as determined by seated office BP).
- Plasma uric acid level ≥5 mg/dl
- Ages 18-50
- non-smokers
- Subjects will need to remain in the San Diego area for the duration of the study and be accessible by telephone or email.
Exclusion
- no current smoking in the prior 6 months.
- Any history of any serious medical conditions requiring close monitoring from physicians- such as liver impairment, chronic kidney disease, or diabetes mellitus. Participants not currently under the care of a physician for these conditions will be eligible for the study.
- Any history of gout, hypertension, hypercholesterolemia, morbid obesity.
- Any history of use xanthine oxidase inhibitors, antihypertensives, antiglycemic, and cholesterol lowering medications
- any history of illicit drug use within the last 6 months
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2014
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT01472692
Start Date
October 1 2011
End Date
March 1 2014
Last Update
December 16 2019
Active Locations (1)
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1
Univerisity Of California San Diego
San Diego, California, United States, 92037