Status:
COMPLETED
Impact of Nitrate Ingestion on Protein Synthesis
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Muscle Protein Synthesis
Eligibility:
MALE
70-85 years
Phase:
NA
Brief Summary
A diet rich in leafy green vegetables has been shown to reduce the risk of developing chronic metabolic disease. The health benefits from these particular vegetables may be attributed to their high ni...
Eligibility Criteria
Inclusion
- Male
- Aged between 70-85 years
- BMI \< 30 kg/m2
- Non insulin-dependent diabetes mellitus type 2 patients (T2DM) ( \>1 y since diagnoses)
Exclusion
- Smoking
- Hypertension (according to WHO criteria)\[29\] and/or cardiovascular disease treated with medication containing nitrates and/or having vasodilatory effects
- Use of medication, except for oral blood glucose lowering medication
- Use of insulin
- All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
- HbA1c \> 10.0% (86 mmol/mol)
- Donated blood in last 3 months
- Diagnosed impaired renal or liver function
- Myocardial infarction within the last 3 years
- Gastric acid inhibitors
- Use of anti-coagulants
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT01473576
Start Date
August 1 2011
End Date
December 1 2013
Last Update
April 15 2016
Active Locations (1)
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1
Maastricht University
Maastricht, Limburg, Netherlands, 6229ER