Status:
UNKNOWN
Oxidative Stress Markers Evaluation Before and After Periodontal Treatment of Diabetics Type 2 Patients
Lead Sponsor:
University of Sao Paulo
Collaborating Sponsors:
Federal University of São Paulo
Conditions:
Diabetes Mellitus Type 2
Eligibility:
All Genders
30-70 years
Phase:
EARLY_PHASE1
Brief Summary
Abstract Diabetes mellitus and periodontal diseases are both chronic inflammatory disorders that have a major impact on the health and well being of millions of individuals worldwide. Periodontal dise...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients with type 2 diabetes and chronic periodontitis(more than 30% of the sites involved, AAP, 1999)
- Patients with type 2 diabetes and periodontally healthy (AAP, 1999)
- Patients systemically healthy with chronic periodontitis (more than 30% of the sites involved)
- Patients systemically and periodontally healthy
- Patients with at least 15 natural teeth (excluding 3rd molars).
- At least 30% of sites with probing pocket depth (PD)\> 5 mm and a maximum of 60% sites with PS \<7 mm
- Clinical attachment level (CAL)\> 4 mm
- Visible plaque and bleeding on probing (BOP)
- Patients with type 2 diabetes have to bear the disease for at least five years and have to show a blood percentage of glycated hemoglobin between 6.5% to 8% (UKPDS 1998) at baseline
- Exclusion Criteria
- Individuals with periodontal pockets deeper than 7 mm
- Patients with any other systemic disease (except diabetes type 2)
- Patients who have used medications such as anticoagulants, contraceptives or antidepressants in the past 6 months
- Patients who have used antibiotic and anti-inflammatory drugs in the last 3 months before the of the study
- Smoking
- Pregnancy
- Patients who have received periodontal treatment in the last six months before the start of this study.
Exclusion
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2013
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01475435
Start Date
August 1 2011
End Date
August 1 2013
Last Update
November 21 2011
Active Locations (1)
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1
University of São Paulo
São Paulo, São Paulo, Brazil, 05508-000