Status:
COMPLETED
Orthogonal Polarisation Study in Young, Elderly and Type 2 Diabetics
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Type 2 Diabetes Mellitus
Eligibility:
MALE
20+ years
Phase:
NA
Brief Summary
Aging is accompanied by a progressive loss of skeletal muscle mass and strength, leading to the loss of functional capacity and an increased risk of developing chronic metabolic disease. One of these ...
Detailed Description
To fulfil the increasing demand for real-time evaluation of micro vascular flow in muscle tissue, new techniques have been evaluated. The conventional systemic hemodynamic and oxygenation parameters a...
Eligibility Criteria
Inclusion
- Male
- Aged between 20-30 or 65-80 years
- BMI \< 30 kg/m2
- Non insulin-dependent Diabetes mellitus type 2 patients. Use of oral anti-diabetic agents (TZD's, Metformin and/or a sulfonylurea derivative) is allowed.
Exclusion
- Positive history for hypertension
- Smoking
- Hypertension (according to WHO criteria)18
- Use of medication, except for oral blood glucose lowering medication
- All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders and paralysis).
- HbA1c \> 10.0%
- Diagnosed impaired renal or liver function
- Obesity (BMI\>30 kg/m2)
- Cardiac disease or cardiovascular problems in history
- Overt diabetic complications
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2014
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT01476384
Start Date
October 1 2010
End Date
March 1 2014
Last Update
April 11 2014
Active Locations (1)
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1
Maastricht University Medical Center+
Maastricht, Limburg, Netherlands, 6229ER