Status:
TERMINATED
Effects of Mutations of the Glycine Gene Associated With Hyperekplexia on Central Pain Processing
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Conditions:
Hyperekplexia
Eligibility:
All Genders
7+ years
Phase:
NA
Brief Summary
Mutations in genes affecting pain transmission start to be known, the investigators are investigating a mutation in a glycine channel, which has an influence on pain modulation. Pain modulation is the...
Detailed Description
Background Hyperekplexia, also known as hereditary startle disease or stiff baby syndrome, is a rare neurogenetic non-epileptic disorder characterized by exaggerated persistent startle response and n...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Hyperekplexia
- GLRA1
- GLRB
- SCLA5
- GPHN
- Gephyrin
- ARHGEF9
- Exclusion Criteria
- Age below 7 years
- Pregnancy
- Breast feeding
- Ongoing medication
- Cognitive impairment
Exclusion
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT01476514
Start Date
October 1 2011
End Date
December 1 2012
Last Update
September 4 2014
Active Locations (1)
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1
Dep. of Anesthesia and Pain medicine, Bern University Hospital
Bern, Canton of Bern, Switzerland, 3010