Status:
COMPLETED
Efficacy of Plant Sterol-Fortified Dairy Product on Plasma Lipid and Plant Sterol Concentrations in Humans
Lead Sponsor:
University of Manitoba
Conditions:
Hypercholesterolemia
Eligibility:
All Genders
19-60 years
Phase:
NA
Brief Summary
The aim of this clinical study was to determine the efficacy on plasma cholesterol-lowering of a water dispersible formulation of plant sterol (WD-PS) preparation versus plant sterol esters (PS-ester)...
Detailed Description
Forty-seven hyperlipidemic subjects (25 males and 22 females, age 19-75 years at baseline) completed the double-blind, randomized, crossover study.
Eligibility Criteria
Inclusion
- healthy individuals aged 19-60 yr
- plasma LDL-C levels \> 3.0mmol/l
- TG \< 4.5mmol/l
- body mass index (BMI) between 20 and 30 kg/m2.
Exclusion
- history of recent or chronic use of oral hypolipidemic therapy, including fish oils, or probucol within the last 3 months
- history of chronic use of alcohol (\>2 drinks/d)
- smoking
- myocardial infarction, coronary artery bypass, sitosterolaemia, kidney disease, liver disease or other major surgical procedures within the last six months
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2011
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT01478789
Start Date
September 1 2010
End Date
October 1 2011
Last Update
December 21 2011
Active Locations (1)
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1
Richarson Centre for Funtional Foods and Nutraceuticals
Winnipeg, Manitoba, Canada, R3T 2N2