Status:
UNKNOWN
Difference of Plasma Orexin A Levels Between Elderly and Young Patients at Emergence
Lead Sponsor:
Xijing Hospital
Conditions:
Anesthesia
Eligibility:
All Genders
18-80 years
Brief Summary
The current study is designed to investigate the difference of plasma orexin A levels between elderly and young patients at emergence from sevoflurane-fentanyl anesthesia who will undergo elective lum...
Detailed Description
BACKGROUND:A specific group of neurons in the brain produces hypocretin, also called orexin, a peptide which has been established as an important regulator of anesthesia and emergence in the latest fe...
Eligibility Criteria
Inclusion
- Participant is Adult (≥18 years old )
- Participants with a Body Mass Index (BMI) 20-25 kg/m2 at the prestudy (screening) visit.
- Participants with ASA physical status Ⅰor Ⅱ
- Participants with Heart function rating Ⅰor Ⅱ
- Glucose of patients is lower than 8 mmol/L
- patients will undergo elective lumbar surgery
Exclusion
- Participant is a pregnant woman or a nursing mother.
- Participants have a history of narcotics allergic reactions
- indices of liver or kidney function is twice higher than normal
- Participants have a history or diagnosis of depression
- Participants have a history of Brain Trauma
- Participants have a history of narcotics addiction or drug addiction
- Participants have a history or diagnosis of adrenal gland diseases
- Participants or his family have an International Classification of Sleep Disorders diagnosis of OSA
Key Trial Info
Start Date :
July 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2012
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01478906
Start Date
July 1 2011
End Date
September 1 2012
Last Update
May 15 2012
Active Locations (1)
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1
Anesthesiology department of Xijing Hospital
Xi'an, Shaanxi, China, 710032