Status:
COMPLETED
The Effect of Central Insulin on Insulin Sensitivity and Energy Metabolism
Lead Sponsor:
German Diabetes Center
Conditions:
Diabetes
Eligibility:
All Genders
30-70 years
Phase:
PHASE4
Brief Summary
Insulin has a direct effect on the energy metabolism of the brain under basal conditions and has an effect on the hepatic glucose production, lipid metabolism and the secretion of various hormone. The...
Detailed Description
Insulin has a direct effect on the energy metabolism of the brain under basal conditions and has an effect on the hepatic glucose production, lipid metabolism in the mouse model. The purpose of this ...
Eligibility Criteria
Inclusion
- Age ≥ 30 and ≤ 70 years
- balanced gender ratio (50: 50)
- BMI 20-25 kg/m² (normal weight subjects)
- BMI 25-35 kg/m² (obese subjects)
Exclusion
- acute illness within the last 2 weeks before the examination
- autoimmune diseases and disorders immune- compromised (leukocytes \<5000/μl)
- renal insufficiency (creatinine\> 1.5 mg / dl)
- heart disease, condition after heart attack
- anemia (Hb \<12 g / l, controls at each examination), blood donation within 4 weeks before the examination
- participation in another study within 2 months before the examination
- wear a metal or magnetic objects on or in the body
- claustrophobia
- use of immunomodulatory drugs (cortisol, antihistamines, aspirin)
- thyroid disease
- taking glitazones and insulin therapy
- pregnancy, lactation, menstruation
- cigarette smoking, use of alcohol or drugs, psychiatric disorders
- risk for / or manifest AIDS (HIV) or hepatitis B or C
- liver disease is not attributed to the existence of a non-alcoholic steatosis
- night shift work or circumstances, which do not allow the normal day-night rhythm
- bleeding disorders or disorders in wound healing
- hypersensitivity to local anesthetics
- malignant cancer
- heart rhythm disorders
- polyneuropathy
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01479075
Start Date
August 1 2011
End Date
June 1 2014
Last Update
June 5 2023
Active Locations (1)
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1
German Diabetic Center
Düsseldorf, North Rhine-Westphalia, Germany, 40225