Status:
COMPLETED
Effect of Recombinant Human Granulocyte Colony- Stimulating Factor on CD11b in Septic Neonates
Lead Sponsor:
Ain Shams University
Conditions:
Neonatal Sepsis
Eligibility:
All Genders
Up to 4 years
Phase:
PHASE4
Brief Summary
The investigators aimed to evaluate the effect of G-CSF administration in septic neonates on neutrophil production and CD11b expression.
Detailed Description
Neonates are susceptible to septicemia secondary to quantitative and qualitative neutrophilic defects. Granulocyte-colony stimulating factor (G-CSF) stimulates myeloid progenitor cell proliferation an...
Eligibility Criteria
Inclusion
- newborn infants with postnatal age \< 28 day,
- minimum gestational age of 28 weeks and requiring intensive care with clinical signs consistent with the diagnosis of neonatal sepsis,
- with or without neutropenia
Exclusion
- neonates with congenital malformation,
- major chromosomal abnormalities,
- prior use of cytokines or intravenous immunoglobulin, or decreased hemoglobin and/or hematocrit at or below the levels necessitate transfusion
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2010
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT01479114
Start Date
April 1 2009
End Date
May 1 2010
Last Update
November 28 2011
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