Status:
COMPLETED
Bronchial Inflammation of Small Airways in Patients With Cystic Fibrosis
Lead Sponsor:
Johann Wolfgang Goethe University Hospital
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
6-60 years
Brief Summary
In the planned study, 60 patients with mild cystic fibrosis (CF) with and without the involvement of small airways (small airway disease - SAD) are to be compared with a historical control group match...
Detailed Description
Aim of this study is the characterization of patients with mild cystic fibrosis in terms of lung function, bronchial hyperreactivity and the degree of systemic and bronchial inflammation. Sputum and ...
Eligibility Criteria
Inclusion
- informed consent
- confirmed diagnosis of CF (known mutations and/or sweat chloride test \> 60mval/l)
- age between 6 and 60 years
- vital capacity \> 75%
- Ability to perform lung function tests and inhalation
Exclusion
- \< 6 and \> 60 years of age on the day of written informed consent
- Acute illness with systemic or bronchial inflammation
- every chronic condition or infection (eg HIV, tuberculosis, malignancy)
- pregnancy
- known alcohol and/ or drug abuse
- Inability to understand the extent and scope of the study
- Participation in another study
Key Trial Info
Start Date :
June 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01479166
Start Date
June 1 2011
End Date
May 1 2012
Last Update
October 29 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Children's Hospital, Johann Wolfgang Goethe-University
Frankfurt am Main, Hesse, Germany, 60590