Status:
WITHDRAWN
Predictors of Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis
Lead Sponsor:
Mayo Clinic
Conditions:
Gastroesophageal Reflux Disease
Eosinophilic Esophagitis
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
PHASE2
Brief Summary
The investigators will determine the prevalence of gastroesophageal reflux disease (GERD) in Eosinophilic Esophagitis (EoE) and importantly determine the predictors of response to Proton Pump Inhibito...
Eligibility Criteria
Inclusion
- 18 years of age \< 80 years of age
- 14 eosinophils / hpf on biopsies from esophagus
- Abnormal validated Mayo dysphagia questionnaire (MDQ-30) (question 2"yes", question 4 \> "moderate" and question 7 \> "once a week")
- Clinically performed EGD with \> 14 eosinophils/hpf completed within last 3 months
Exclusion
- Other cause of dysphagia identified at endoscopy (e.g. stricture, web, infection, ring, achalasia, esophageal neoplasm)
- Dilatation of esophagus at time of index endoscopy
- Treatment with topical steroid within 3 months of index endoscopy
- Treatment with PPI in last 30 days prior to index EGD
- Patient population - adults with EoE recruited from Mayo Clinic Rochester, MN patient population
Key Trial Info
Start Date :
March 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2012
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01479231
Start Date
March 1 2012
End Date
March 1 2012
Last Update
April 19 2012
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