Status:
COMPLETED
Side Effects of 4 Times Bone Marrow Mono Nuclear Transplantation in Patients With Ischemic Lower Limb
Lead Sponsor:
Royan Institute
Conditions:
Ischemic Ulcer
Eligibility:
All Genders
20-62 years
Phase:
PHASE1
PHASE2
Brief Summary
Critical limb ischemia (CLI) results from severe occlusive disease that impairs distal limb perfusion to the point where oxygen delivery is no longer adequate to meet the metabolic needs of the tissue...
Detailed Description
In this study we transparent bone marrow derived mononuclear stem cells 4 times to the ischemic limb of 11 patients with PAD.first of all all the patients evaluate by physical examination,PFWD,ABI and...
Eligibility Criteria
Inclusion
- Ischemic lower limb based on TASK guide line
- Rutherford score:2,3
- ABI\<0.6
- Absolute ankle pressure \< 60 mmHg
- Both gender
- Age:20-62years
Exclusion
- EF\<30%
- Cr\>2
- HbA1c\>8%
- Bone marrow disorders:leukemia
- Cognitive disorders
- Infections
- MI with ST elevation during last month
- Malignancy
- Immunologic or rheumatologic disorders
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01480414
Start Date
September 1 2010
End Date
May 1 2012
Last Update
December 27 2012
Active Locations (1)
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1
Royan Institute
Tehran, Iran