Status:
COMPLETED
Preventing Pain After Heart Surgery
Lead Sponsor:
Barts & The London NHS Trust
Conditions:
Pain
Hyperalgesia
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
The use of pre-emptive analgesia to prevent pain following sternotomy for cardiac surgery
Eligibility Criteria
Inclusion
- Informed Consent
- First time sternotomy for all cardiac surgery
- Patient aged 18 - 80 years
Exclusion
- Emergency surgery (decision to operate taken on the day of surgery)
- Previous sternotomy
- Preoperative renal failure (eGFR \<60 ml/min)
- History of chronic non-anginal pain
- Chronic pain medication other than paracetamol and non-steroidal anti-inflammatory drugs
- Concurrent use of oxycodone, lorazepam, or ethanol.
- Concurrent use of any drugs for neuropathic pain e.g. antiepileptics, antidepressants
- Allergy to pregabalin, gabapentin or ketamine
- Pregnancy
- Limited understanding of numerical scoring scales
- Previous participation in other trials investigating analgesic agents or any IMP in previous three months
Key Trial Info
Start Date :
December 12 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 7 2013
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT01480765
Start Date
December 12 2011
End Date
March 7 2013
Last Update
November 5 2024
Active Locations (1)
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1
Pain and Ananesthesia Research Centre, Barts and The London NHS Trust
London, United Kingdom, EC1A 7BE