Status:
COMPLETED
Sildenafil for Post-capillary Pulmonary Hypertension in Patients Undergoing Cardiac Surgery
Lead Sponsor:
University of Turin, Italy
Conditions:
Pulmonary Hypertension
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Pulmonary hypertension increases the perioperative risk in patients undergoing cardiac surgery for valvular heart diseases, especially in patients with a long life mitral valve disease. The present st...
Detailed Description
Pulmonary hypertension represents an increased risk for perioperative patients undergoing cardiac surgery for valvular heart disease especially in patients with a long life mitral valve disease compli...
Eligibility Criteria
Inclusion
- all patients undergoing valvular heart surgery associated to post capillary pulmonary hypertension with a mean pulmonary arterial pressure (mPAP)\>30mmHg or pulmonary vascular resistance (PVR)\>3Wu.
Exclusion
- patients younger than 18 years old
- ischemic cardiomyopathy
- Ejection Fraction (EF)\<30%
- severe Chronic obstructive pulmonary disease (COPD) with oxygen and bronchodilators therapy
- chronic pulmonary disease, chronic renal failure on dialysis
- hepatic failure
- patients with orotracheal intubation and already admitted to the ICU before the intervention
Key Trial Info
Start Date :
February 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01481350
Start Date
February 1 2012
End Date
December 1 2013
Last Update
December 9 2014
Active Locations (1)
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1
San Giovanni Battista Hospital University of Turin
Turin, Turin, Italy, 10126