Status:
COMPLETED
Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF)
Lead Sponsor:
Jens Faber
Conditions:
Heart Failure
Low T3 Syndrome
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Purpose: The purpose of the study is to examine if treatment with liothyronine increases left ventricular ejection fraction (LVEF) in patients with stable, chronic heart failure.
Detailed Description
The patients are examined 3 times. At baseline, after 3 months and after 6 months.After the examination is performed, they begin the study medication while admitted at Dept. of Cardiology, Herlev Hosp...
Eligibility Criteria
Inclusion
- Patients with stable, chronic systolic heart failure
- T3 ≤1.4 nmol/l in two blood samples, TSH is to be normal
- LVEF ≤ 45 % on prior echocardiography
Exclusion
- Established thyroid illness
- Atrial fibrillation/flutter
- More than 20% ventricular extrasystoles
- Severe chronic obstructive lung disorder
- Pregnancy. Pregnancy testing will be done for fertile women
- Age \< 18 years
Key Trial Info
Start Date :
July 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2014
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT01481402
Start Date
July 1 2011
End Date
February 1 2014
Last Update
July 16 2019
Active Locations (1)
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1
Herlev Hospital, Dept. of Endocrinology
Herlev, Denmark, 2730