Status:
COMPLETED
Risk of Hepatitis B Reactivation After Bone Marrow Transplantation With Prior Hepatitis B Virus (HBV) Exposure
Lead Sponsor:
The University of Hong Kong
Conditions:
Exposure to Hepatitis B Virus
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to determine whether preemptive nucleoside analogue therapy or regular virologic monitoring is the preferred method in management patients with prior exposure to hepatitis...
Detailed Description
Occult hepatitis B virus (HBV) reactivation has been documented in bone marrow transplantation recipients who are hepatitis B surface antigen (HBsAg)-negative but with serologic evidence of prior expo...
Eligibility Criteria
Inclusion
- Documented HBsAg-negative HSCT recipient with or without antibody to the hepatitis B surface antigen (anti-HBs).
- Documented anti-HBc (total)-positive.
Exclusion
- Concomitant liver diseases including chronic hepatitis C and D infection, Wilson's disease, autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis.
- Significant alcohol intake (\>30 grams per day)
Key Trial Info
Start Date :
November 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2016
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT01481649
Start Date
November 1 2011
End Date
February 1 2016
Last Update
April 14 2016
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Medicine, The University of Hong Kong, Queen Mary Hospital
Hong Kong, Hong Kong