Status:
UNKNOWN
Magnesium for Neonatal Neuroprotection and Mothers
Lead Sponsor:
University of British Columbia
Conditions:
Premature Birth
Sedation During Labor and Delivery; Complications, Pulmonary
Eligibility:
FEMALE
19+ years
Brief Summary
Magnesium is a treatment for mothers to protect brains of babies born early. This study investigates combined effects of magnesium and spinal or epidural anesthesia on mothers having cesareans. The i...
Detailed Description
1. Purpose Neonatal neuroprotection is a new indication for magnesium. Meta-analysis of the available literature suggests beneficial neonatal outcomes, but the direct effects on maternal health ha...
Eligibility Criteria
Inclusion
- Delivering by cesarean section at less than 34 weeks gestational age (maximum 33 weeks and 6 days).
- ≥19 yr
- Singleton or multiple pregnancy
- o There is potentially greater intra-abdominal pressure associated with multiple pregnancies, which may affect anesthetic block height by increasing blood volume in epidural blood vessels. It may also increase the risk of basal atelectasis and will affect respiratory mechanics to a greater extent. We plan to undertake sub-group analysis to test this effect.
- Primiparous or multiparous
- English-speaking
- Undergoing cesarean section with neuraxial anesthesia (intrathecal, epidural or combined spinal epidural \[CSE\]).
- Parturients response may not be identical to the different neuraxial techniques, e.g. the degree of respiratory motor blockade exhibited or onset of opioid effect. Therefore we plan to undertake sub-group analysis to test this effect.
Exclusion
- Illegal, non-prescription drug use within the last year
- Psychiatric disorder treated with medication within the last year
Key Trial Info
Start Date :
January 26 2012
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2019
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01482078
Start Date
January 26 2012
End Date
July 1 2019
Last Update
October 12 2018
Active Locations (1)
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1
BC Women's Hospital
Vancouver, British Columbia, Canada, V6H 3N1