Status:
COMPLETED
Vascular Effect of Estrogens Versus Placebo Evaluated by Flow-mediated Dilatation of Brachial Artery
Lead Sponsor:
Federal University of Minas Gerais
Conditions:
Unspecified Injury of Brachial Artery, Left Side, Initial Encounter
Eligibility:
FEMALE
45-65 years
Phase:
NA
Brief Summary
The aim of this study is to evaluate the vascular effects of estrogens on climacteric women measured by flow-mediated evaluation of the brachial artery using high resolution ultrasound and compare to ...
Detailed Description
The interruption of the secretion of sex steroids that occurs after menopause, determines a change in vascular pattern at various levels. As a result, several side effects might appear and interfere w...
Eligibility Criteria
Inclusion
- Women without menstrual cycles within the last 12 months and FSH \> 30IU/L
- Healthy women
- Women that were not using drugs with potential vascular effect within the last 1 year
- Women that never used hormone replacement therapy
Exclusion
- Smoking
- Blood Pressure \> 160/90 mm Hg.
- Breast and or endometrial cancer
- History of acute myocardial infarction
- Diabetes
- Vaginal bleeding of any origin
- Hepatic disease
- Thrombophlebitis or thromboembolic disorders
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2014
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01482416
Start Date
November 1 2011
End Date
August 1 2014
Last Update
August 15 2014
Active Locations (1)
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1
Hospital das Clinicas - Universidade Federal de Minas Gerais
Belo Horizonte, Minas Gerais, Brazil, 30130100