Status:
COMPLETED
Fat and Transcapillary Insulin Transport
Lead Sponsor:
German Diabetes Center
Collaborating Sponsors:
Medical University of Vienna
Conditions:
Lipid-induced Insulin Resistance
Eligibility:
MALE
20-45 years
Phase:
NA
Brief Summary
There is a current debate whether impaired insulin-mediated microvascular perfusion limits the delivery of hormones and nutrients to muscle and whether short term FFA elevation affects transcapillary ...
Detailed Description
Increased lipid availability reduces insulin-stimulated glucose disposal in skeletal muscle, which is generally explained by lipid induced inhibition of myocellular insulin signalling, It remains uncl...
Eligibility Criteria
Inclusion
- The volunteers have to be older than 19 years,
- nonobese (body mass index, BMI less than 27 kg/m2),
- normolipidemic (fasting serum concentration of triglycerides \< 140 mg/dL and
- total cholesterol \< 200 mg/dL) and
- non-smokers.
Exclusion
- The following exclusion criteria will be applied:
- any medication within two weeks prior to the start of study,
- regular alcohol consumption \> 40 g/d,
- acute inflammatory disease defined by serum C-reactive protein \> 1 mg/dL,
- abnormalities in the screening visit or in laboratory tests considered as clinically relevant,
- family history of diabetes mellitus or dyslipidemia,
- glucose intolerance,
- allergy or hypersensitivity against study medication,
- blood clotting disorders.
Key Trial Info
Start Date :
December 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2012
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT01482455
Start Date
December 1 2011
End Date
August 1 2012
Last Update
June 15 2023
Active Locations (1)
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1
Medical University Vienna
Vienna, Austria, 1090