Status:
COMPLETED
Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone
Lead Sponsor:
B.P. Koirala Institute of Health Sciences
Conditions:
Anxiety
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
Background: Benzodiazepine, a common premedicant, suppresses endogenous melatonin levels and thus paradoxically increases episodes of arousal during sleep and thus causes restlessness and hangs over e...
Detailed Description
Review of literature: Benzodiazepines are among the most popular drugs used for preoperative medication to produce anxiolysis, amnesia, and sedation. However, they negatively influence sleep quality ...
Eligibility Criteria
Inclusion
- (ASA 1\&2),
- aging 18 to 65 years
- having anxiety VAS score of more than 2
- posted for general anaesthesia with estimated duration of \< 3 hours.
Exclusion
- patients taking analgesics, sedatives, antiepileptics or antidepressants,
- suffering from obesity (BMI ≥ 28) or neuropsychiatric disease,
- having allergy to the study drugs
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT01486615
Start Date
October 1 2011
End Date
January 1 2012
Last Update
October 5 2012
Active Locations (2)
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1
B. P. Koirala Institute of Health Sciences
Dharān, Koshi, Nepal, 56700
2
Dr Krishna Pokharel
Dharān, Koshi, Nepal, 56700