Status:
COMPLETED
What is the Impact of Early Life Exposures on the Cardiovascular System in Young Adulthood?
Lead Sponsor:
University of Oxford
Conditions:
Preterm Birth
Eligibility:
All Genders
20-40 years
Brief Summary
The purpose of this study is to investigate whether early life exposures such as premature birth or exposure to preeclampsia before you are born results in long-term alterations in the cardiovascular ...
Detailed Description
While the incidence of cardiovascular disease has reduced dramatically, coinciding with favourable changes in risk factors, cardiovascular disease remains the single largest cause of mortality and pre...
Eligibility Criteria
Inclusion
- Participant is willing and able to give informed consent for participation in the study.
- Preterm-born Cohort: Born premature (\<37 weeks completed gestation), originally recruited as part of a randomised feeding trial at birth from one of five United Kingdom centres between 1982 and 1985.
- Term-born Cohort: Born at term (\>37 weeks completed gestation) with normal birth weight for gestational age.
- Able (in the Investigator's opinion) and willing to comply with all study requirements.
Exclusion
- The participant may not enter the study if ANY of the following apply:
- Unwilling or unable to give informed consent for participation in the study.
- Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study.
- Contraindication to Cardiovascular Magnetic Resonance Imaging.
Key Trial Info
Start Date :
May 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2015
Estimated Enrollment :
234 Patients enrolled
Trial Details
Trial ID
NCT01487824
Start Date
May 1 2007
End Date
October 1 2015
Last Update
January 8 2019
Active Locations (1)
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1
Cardiovascular Clinical Research Facility, Dept of Cardiovascular Medicine, University of Oxford
Oxford, Oxfordshire, United Kingdom, OX3 9DU