Status:
COMPLETED
Use of Diazoxide in Acute Hypoglycaemia
Lead Sponsor:
University of Dundee
Collaborating Sponsors:
Juvenile Diabetes Research Foundation
Conditions:
Type 1 Diabetes
Eligibility:
All Genders
18-55 years
Phase:
PHASE4
Brief Summary
The investigators know that intensive insulin therapy and tight glucose control is associated with reduction of diabetic complications. However, many patients on insulin don't achieve this because of ...
Detailed Description
This will be conducted in a double blinded (neither subject nor the researcher will know the order of the IMP(drug/placebo). All subjects will receive both the active drug and placebo in a random fash...
Eligibility Criteria
Inclusion
- Healthy adults (aged 18-55) with \>5 years disease duration
- On intensive insulin therapy (CSII or multiple daily injections)
- HbA1C\<8.0%
- Ability to give written informed consent to participate in the study
- BMI between 20-29
Exclusion
- History of significant cardiac, hepatic, renal or neurological disease.
- Significant head injury, epilepsy or hypoglycaemia-induced seizures.
- Pregnancy.
- Breast feeding mothers.
- Participants on thiazide diuretics
- Participants on other potassium channel openers (nicorandil, minoxidil)
- Participants on medications with vasodilatory properties such as methyldopa, reserpine, theophyllines and nitrites.
- Participants on hydantoins (fosphenytoin, phenytoin)
- Significant anaemia Hb\<11.0 and Hct\<33%.
- If they have donated blood in the last 30 days.
- All those who have participated in a CTIMP in the last 3 months
- Participants who are already on diazoxide or who have a past history of allergy to diazoxide
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2013
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01488136
Start Date
January 1 2012
End Date
March 1 2013
Last Update
October 14 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
NHS Tayside
Dundee, United Kingdom, DD1 9SY