Status:
COMPLETED
Rosuvastatin Effect on Serial Echocardiographic Measurement of Coronary Flow Velocity Reserve
Lead Sponsor:
Asan Medical Center
Collaborating Sponsors:
AstraZeneca
Conditions:
Hypertension
Cardiovascular Risk Factors
Eligibility:
All Genders
35-80 years
Phase:
PHASE4
Brief Summary
In ASCOT study, lipid lowering with a statin provided additional beneficial effects in hypertensive patients with average levels of serum total cholesterol. However, the underlying mechanism of statin...
Detailed Description
In hypertensive patients with high risk, lipid lowering with a statin provided additional beneficial effects in hypertensive patients with average levels of serum total cholesterol. However, the under...
Eligibility Criteria
Inclusion
- Controlled Hypertension: treated SBP \< 140 mmHg and DBP \< 90 mmHg
- LDL cholesterol \> 130 mg/dL
- Patients with statin-naive state, defined as receiving no statin therapy for more than 3 months during the previous 12 months
- Any 1 of these cardiovascular risk factors required: smoking, Type 2 DM, age over 55 (men) or 65 (women), peripheral vascular disease, history of cerebrovascular event, family history of early CHD before age 55, HDL cholesterol \< 40 mg/dL
Exclusion
- A previous history of intolerance or hypersensitivity to statins
- Uncontrolled hypertension; SBP ≥ 140 mmHg or DBP ≥ 90 mmHg
- Previous MI or currently treated angina pectoris
- Stroke, Transient ischemic attack \< 3 months
- Secondary hypertension
- Fasting serum triglyceride \> 500 mg/dL
- Clinical congestive heart failure
- Uncontrolled arrhythmia
- Left ventricular hypertrophy: LV mass index \> 134g/m2 (male) or \>110g/m2 (female)
- Concomitant clinically important respiratory, hematological, gastrointestinal, hepatic, renal or other disease
- Pregnant or lactating women and those of child-bearing potential
Key Trial Info
Start Date :
December 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2013
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT01490398
Start Date
December 1 2011
End Date
October 1 2013
Last Update
May 9 2014
Active Locations (1)
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1
Asan Medical Center
Seoul, South Korea, 138-736