Status:
UNKNOWN
Study of the Effect of Vagus Nerve Stimulation on Human Brown Adipose Tissue Activity
Lead Sponsor:
Maastricht University
Conditions:
Obesity
Eligibility:
All Genders
18-65 years
Brief Summary
To evaluate the effect of vagus nerve stimulation for refractory epilepsy on the activity of human brown adipose tissue.
Eligibility Criteria
Inclusion
- Subjects treated with VNS for epilepsy, aged 18-65 years, with a Body Mass Index (BMI) ≤ 28 kg/m2.
Exclusion
- Body Mass Index \> 28 kg/m2
- Daily epileptic insults.
- Subjects that need 'Rapid Cycling' VNS to control their frequency of epileptic insults.
- Psychological unstable subjects (as judged by the treating neurologist).
- subjects with mental retardation (as judged by the treating neurologist).
- subjects with severe behaviour disorders (as judged by the treating neurologist).
- Pregnant subjects.
- Subjects that previously underwent high dose radiation for diagnostic or therapeutic purposes (radiotherapy, high frequency CT-scans).
- The use of the following medication is an exclusion criterium;
- ß-blockers,
- Ketogenic diet
Key Trial Info
Start Date :
January 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2012
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT01491282
Start Date
January 1 2011
End Date
November 1 2012
Last Update
December 13 2011
Active Locations (1)
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1
Maastricht University
Maastricht, Netherlands, 6200MD