Status:
COMPLETED
Brain Derived Neurotrophic Factor Serum Levels Evolution During the Six Months After Alcohol Withdrawal
Lead Sponsor:
Centre Hospitalier Esquirol
Conditions:
Alcohol Dependence
Eligibility:
All Genders
18+ years
Brief Summary
Alcohol dependence is accompanied by several neurological mechanisms involving neuronal plasticity and neoneurogenesis, requiring Brain Derived Neurotrophic factor (BDNF) synthesis. The investigators...
Detailed Description
A total of 205 patients will be recruited at their hospitalization time for alcohol withdrawal during a 18 months period. The follow-up at 14, 28 days, 2, 4, 6 months after alcohol withdrawal will ass...
Eligibility Criteria
Inclusion
- Diagnosis of alcohol dependence according to the DSM-IV-TR
- Request for withdrawal
Exclusion
- Age \< 18 years
- Psychiatric co-morbidity in an evoluting stage and predominant on the addiction trouble
- Characterized (diagnosed) neurological co-morbidity
- Severe somatic pathology and / or with fatal predicted outcome in the year (cancer...)
- Inability to answer the questionnaires
- pregnancy
- neuroleptic or antidepressant treatment established for less than 3 months
- anti-retroviral treatment
- absence of consent, judiciary protection, hospitalization under constraint, - absence of health insurance.
- Residence at more than 80 km from the study center
- Participation to an other biomedical study during the 6 months of the study
Key Trial Info
Start Date :
November 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
389 Patients enrolled
Trial Details
Trial ID
NCT01491347
Start Date
November 1 2011
End Date
December 1 2016
Last Update
January 31 2017
Active Locations (4)
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1
Clinique Saint Maurice
La Jonchère, France, 87340
2
Centre Hospitalier Esquirol
Limoges, France, 87000
3
Centre Hospitalier de Vauclaire
Montpon-Ménestérol, France, 24700
4
Centre Hospitalier La Vallette
Saint-Vaury, France, 23300