Status:
COMPLETED
The Study of Minocycline for Negative and Cognitive Symptoms in Schizophrenia
Lead Sponsor:
Central South University
Conditions:
Schizophrenia
Eligibility:
All Genders
18-40 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether minocycline are effective in the treatment of negative and cognitive symptoms in schizophrenia.
Detailed Description
Immune-related disorders have been hypothesized as etiological factors in schizophrenia.Minocycline is a second-generation tetracycline that exerts anti-inflammatory and antimicrobial effects while ha...
Eligibility Criteria
Inclusion
- male and female,were aged 18-40 years
- were currently diagnosed with DSM-IV schizophrenia
- were able to comprehend the cognition test
- patients or guardian signed informed consent,were able to comprehend the procedure and aims of the study,agreed to join the study
- patient's current antipsychotic medication regimen must be stable
- must be in a stable living arrangement
Exclusion
- had ever been hypersensitivity to minocycline or tetracycline;
- had acute,unstable,significant,or untreated medical illness besides schizophrenia
- were pregnant or breast-feeding;
- had a DSM-IV diagnosis of substance abuse or dependency;
- had a tendency to suicide or Violence,self-harm;
- had taken immunosuppressive agents in the preceding 3 months before study entry;
- had influenza or fever in the preceding 2 weeks before study entry;
- had a DSM-IV diagnosis of emotional psychosis,Mental retardation,etc.
- has suicidal attempts or ideation or violent behavior within the last 12 months
- patient has mental retardation or severe organic brain syndromes
- treatment with Electroconvulsive Therapy (ECT) within 6 months prior to screening
Key Trial Info
Start Date :
June 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT01493622
Start Date
June 1 2010
End Date
December 1 2011
Last Update
December 16 2011
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical College
Kunming, Yunnan, China, 650031