Status:
COMPLETED
Two Step Versus the Standard Three Step Approach of the WHO Analgesic Ladder for Cancer Pain Relief.
Lead Sponsor:
University of Edinburgh
Collaborating Sponsors:
NHS Lothian
Conditions:
Cancer
Pain
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The World Health Organization analgesic ladder for cancer pain relief is an internationally used approach to managing cancer pain. Patients generally start on Step 1 of the ladder (paracetamol). As pa...
Eligibility Criteria
Inclusion
- 18 years of age and over.
- Patient has a cancer diagnosis (based on radiological, histological, cytological, or operative evidence). Those with haematological malignancies are eligible.
- Cancer related pain - which in the opinion of the clinician is caused by the presence of tumour or metastases.
- Average pain score \> 4, on a numerical rating scale from 0-10, requiring step 2 analgesia (weak opioid).
- Patient is able to comply with trial procedures.
Exclusion
- Patients who have received radiotherapy in the previous 6 weeks or are planned to receive radiotherapy during the trial period where in either case, it is expected to affect pain during the trial period.
- Pain due to surgery in the preceding 4 weeks.
- Life expectancy less than two months (based on clinical impression).
- Patients with psychotic disorders or cognitive impairment.
- Patients who have received regular doses (scheduled doses - NOT as required dosing) of weak or strong opioids in the preceding two weeks.
- Patients using immediate release opioids \> 2 doses/24 hours, in the previous 24 hours.
Key Trial Info
Start Date :
November 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2016
Estimated Enrollment :
152 Patients enrolled
Trial Details
Trial ID
NCT01493635
Start Date
November 1 2012
End Date
March 1 2016
Last Update
May 17 2017
Active Locations (1)
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1
Western General Hospital
Edinburgh, United Kingdom, EH4 2XU