Status:
COMPLETED
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory
Lead Sponsor:
Centre for Addiction and Mental Health
Conditions:
Schizophrenia
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Deficits in working memory (WM) performance are the most significant cognitive impairments in schizophrenia (SCZ). It has also been shown that WM performance is contingent on the cortex synchronizatio...
Detailed Description
To directly investigate whether enhanced gamma synchrony mediates rTMS enhancement of WM in patients with SCZ, and in healthy individuals the investigators propose the following study. The relationshi...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Schizophrenia Subjects:
- Voluntary and competent to consent
- SCID-IV Diagnosis of Schizophrenia or Schizoaffective Disorder
- Between the ages of 18 and 85
- Inclusion Criteria for Healthy Subjects:
- voluntary and competent to consent
- between the ages of 18-85
- considered a healthy individual free of psychopathology based on the Personality Assessment Inventory
- right-handed determined by the TMS screening and demographic form
- self-reported non-smoker
- do not have a self-reported concomitant major medical or neurologic illness
- if a woman of childbearing potential, must be on an effective means of birth control determined through completion of the TMS screening and demographic form.
- Exclusion Criteria for both Healthy Controls and Schizophrenia Subjects:
- Have a DSM-IV history of substance abuse or dependence in the last 6 months
- Have a concomitant major and unstable medical or neurologic illness
- Have a history of seizures
- Have a first degree relative with a history of a seizure disorder
- Are pregnant
- Have any clinically significant EEG activity indicating an increased risk of seizure, as confirmed by a neurologist.
Exclusion
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
122 Patients enrolled
Trial Details
Trial ID
NCT01494623
Start Date
May 1 2006
End Date
November 1 2012
Last Update
June 11 2013
Active Locations (1)
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1
Centre for Addiction and Mental Health
Toronto, Ontario, Canada, M6J 1H4