Status:
TERMINATED
Impact of Inhaled Treprostinil Sodium on Ventilation Perfusion Matching
Lead Sponsor:
University of Florida
Collaborating Sponsors:
United Therapeutics
Conditions:
Pulmonary Arterial Hypertension
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
18-80 years
Brief Summary
The purpose of this study is to see how inhaled treprostinil sodium (Tyvaso) affects the amount of air and blood that reach the alveoli, or tiy air sacs, in the lungs of patients with Group 1 Pulmonar...
Detailed Description
In patients with severe COPD where the FEV1 is 50% or less than predicted, emphysema and obliterating bronchiolitis presenting a "ceiling" to any improvement in function that can be achieved by therap...
Eligibility Criteria
Inclusion
- Subject has a diagnosis of PAH confirmed by right heart catheterization within the last 12 months (defined by mean pulmonary artery pressure of greater than or equal to 25 with pulmonary capillary wedge pressure or left ventricular end-diastolic pressure of less than or equal to 15).
- Subject is being initiated on inhaled treprostinil for treatment of PAH.
- Subject between 18 and 80 years of age at screening with a diagnosis of COPD confirmed by spirometry within the last 6 months showing FEV1 \> 40% predicted and FEV/FVC of \< 70.
- Baseline 6-minute walk distance \> 150 meters.
- Subject has not been on any approved therapy for their PH for the last 90 days.
- If subject is being treated with conventional therapy for COPD, they must be receiving a fixed regimen of these therapies for tat least 30 days prior to Baseline.
- Previous echocardiography with evidence of normal left systolic and diastolic ventricular function, and absence of any clinically significant left sided heart disease.
- If female, physiologically incapable of childbearing or practicing an acceptable method of birth control as deemed appropriate by the physician or institution.
- If female, negative serum pregnancy test required at screening.
- Subject voluntarily gives informed consent.
Exclusion
- The subject is pregnant or lactating.
- Subject has had a new type of chronic therapy for PH added within 90 days of Baseline.
- Subject has had any medication started or discontinued for COPD within 30 days of Baseline.
- Subject has any of the following: portal hypertension, chronic thromboembolic disease, pulmonary veno-occlusive disease or other than those accepted as part of the inclusion criteria or has had any atrial septostomy.
- Subject has a current diagnosis of uncontrolled sleep apnea as defined by their physician.
- Subject has a history or current evidence of left-sided heart disease.
- Subject has interstitial lung disease as evidence by CT scan or restrictive pattern on pulmonary function tests (FEV1/FVC \> 70 and TLC \< 80% predicted) or COPD with FEV1 \< 40% predicted.
- Subject has a musculoskeletal disorder or any other disease that is likely to limit ambulation, or is connected to a machine that is not portable.
- Subject is incapable of maintaining compliance throughout the course of the study.
- Any condition, in the investigator's opinion, would constitute an unacceptable risk to the subject's safety.
- Subject is receiving an investigational drug, has an investigational device in place or has participated in an investigational drug or device study within 30 days prior to screening.
- Subjects without a telephone contact.
Key Trial Info
Start Date :
November 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT01494896
Start Date
November 1 2011
End Date
December 1 2014
Last Update
May 7 2015
Active Locations (3)
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1
University of Florida, Jacksonville
Jacksonville, Florida, United States, 32209
2
Mayo Clinic
Jacksonville, Florida, United States, 32224
3
Cleveland Clinic Florida
Weston, Florida, United States, 33331