Status:
COMPLETED
Innate Immunity and the Allergic Response
Lead Sponsor:
Medical College of Wisconsin
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Conditions:
Nasal Allergies
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of this study is to determine if a certain cell type (the CD49d+ neutrophil) is associated with the presence or development of allergic disease.
Detailed Description
A specific subset of neutrophils (CD49d+) will be recruited to the nasal tissue of individuals with allergic disease, and that these cells will also be found in the peripheral blood of allergic subjec...
Eligibility Criteria
Inclusion
- Must give written informed consent before any study related activity is performed
- Male and female adult and adolescent patients aged ≥18 years and ≤ 65 years.
- Allergic or non-allergic subjects as proven by allergy skin tests in the past 2 years.
Exclusion
- The presence of any of these diseases: Atopic dermatitis, persistent controlled asthma, any level of severity of uncontrolled asthma, immunodeficiency or suspected immunodeficiency, any co-morbid disease (cardiac, congenital, diabetes, renal, gastrointestinal, hematologic, and oncologic).
- Any prior history of immunodeficiency, cardiac, congenital, diabetes, renal, gastrointestinal, hematologic, or oncologic disease.
- The use of any intranasal and inhaled corticosteroids within the last month.
- Current therapy with any medication other than as needed over-the-counter medications or as-needed (not scheduled) antihistamine use.
- Current pregnancy.
- Women of childbearing potential not using an acceptable birth control method, as well as women who are breastfeeding
- Patients with severe medical condition(s) that in the view of the investigator prohibits participation in the study (specify as required)
- Use of any other investigational agent in the last 30 days
Key Trial Info
Start Date :
March 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2013
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT01494948
Start Date
March 1 2012
End Date
March 1 2013
Last Update
January 8 2014
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