Status:
COMPLETED
Combined Donepezil and Selegiline Effects on Cocaine-Reinforced Behavior
Lead Sponsor:
Midwest Biomedical Research Foundation
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine Use Disorders
Eligibility:
All Genders
21-50 years
Phase:
PHASE2
Brief Summary
No medications are currently available for treatment of psychostimulant addiction, a compulsive preoccupation with use of cocaine and related compounds. Donepezil is a medication that is currently pre...
Detailed Description
Background: We have recently shown that pretreatment with certain cholinesterase inhibitors can produce large reductions in cocaine-reinforced behavior in rats (drug self-administration is decreased ...
Eligibility Criteria
Inclusion
- Meets DSM-IV-TR criteria for cocaine abuse or dependence
- At least one cocaine-positive urine within 6 weeks prior to enrollment
- Has used cocaine for a duration of at least 6 months
- At least weekly cocaine use during the last 30 days
Exclusion
- History of a medical adverse reaction to cocaine or other psychostimulants
- Any current Axis I psychiatric disorder other than drug abuse or dependence
- Dependence on abused substances other than cocaine
- Current or past history of seizure disorder
- Heart or lung disease
Key Trial Info
Start Date :
February 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01495195
Start Date
February 1 2012
End Date
May 1 2013
Last Update
December 18 2013
Active Locations (1)
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1
Kansas City VA Medical Center
Kansas City, Missouri, United States, 64128