Status:
COMPLETED
Treatment of Muscle Cramps in Patients With Liver Cirrhosis
Lead Sponsor:
Mayo Clinic
Conditions:
Liver Cirrhosis
Muscle Cramps
Eligibility:
All Genders
21+ years
Phase:
EARLY_PHASE1
Brief Summary
This is a pilot study to see if hydroxychloroquine (HCQ) if safe and effective to use with patients having cramps due to their cirrhotic liver disease.
Detailed Description
This project is proposed as a pilot study to gather preliminary data for a full-scale randomized trial to assess the efficacy and safety of hydroxychloroquine (HCQ) in the treatment of muscle cramps i...
Eligibility Criteria
Inclusion
- previous diagnosis of cirrhosis
- adult (\>21 years)
- able to complete a written questionnaire in English
- stable and ambulatory
- MELD score \< 25, Platelet count \>25,000
Exclusion
- people allergic to hydroxychloroquine, 4-aminoquinolone derivatives or any component of the formulation
- previous diagnosis of retinal or visual field changes attributable to 4-aminoquinolone
- previous diagnosis of porphyria
- previous diagnosis of psoriasis
- fulminant hepatic failure
- pregnant women
Key Trial Info
Start Date :
December 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2015
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT01495403
Start Date
December 1 2011
End Date
April 1 2015
Last Update
May 3 2023
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905