Status:
COMPLETED
Study of Keto Acid (KA) on Insulin Resistance in Peritoneal Dialysis (PD) Patients
Lead Sponsor:
Peking University First Hospital
Collaborating Sponsors:
Vanderbilt University
Conditions:
Insulin Resistance
Eligibility:
All Genders
18-80 years
Phase:
PHASE3
Brief Summary
The overarching aim of this proposal is to examine the effects of usual protein diet supplemented with keto acid (KA) on insulin sensitivity in patients on peritoneal dialysis (PD). The investigators ...
Detailed Description
Specific Aims and Significance: To evaluate the effects of KA plus usual protein diet on basal and stimulated insulin sensitivity in PD patients. Hypothesis: Administration of KA plus usual protein ...
Eligibility Criteria
Inclusion
- medically stable and receiving stable PD \>= 3 months
- age 18-80 years
- body mass index \> 18.5
- Kt/v \>= 1.7 or Tccr \>= 50l/week/1.73m2
- glucose lactate-buffered PD solutions
Exclusion
- pregnancy
- intolerance to the study protocols
- severe, unstable, active, or chronic inflammation disease
- chronic use of anti-inflammatory medication
- severe malnutrition
- a high probability of receiving a kidney transplant or transferring to HD within 6 months
- taking anti-inflammatory medication chronically or taking KA during the past one month
Key Trial Info
Start Date :
April 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01496092
Start Date
April 1 2011
End Date
December 1 2012
Last Update
February 21 2014
Active Locations (1)
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1
Jie Dong
Beijing, Beijing Municipality, China, 100034