Status:
COMPLETED
Effects of Calorie Restriction on Accumulation of Old, Modified Proteins in Abdominally Obese Adults
Lead Sponsor:
Mayo Clinic
Conditions:
Insulin Resistance
Eligibility:
All Genders
45-65 years
Phase:
NA
Brief Summary
This study is being done to understand the effects of calorie restriction and weight loss on muscle protein metabolism in adult men and women.
Eligibility Criteria
Inclusion
- Healthy
- BMI will be between 30 kg/m2 - 38 kg/m2 and waist circumference for women ≥ 88 cm and men ≥ 104 cm
- Age 45 to 65 years.
- Male and Female
Exclusion
- Active coronary artery disease
- BMI \< 30 kg/m2 Participation in structured exercise (\>2 times per week for 30 minutes or longer)
- Smoking
- Medications known to affect muscle metabolism (beta blockers)
- Renal failure (serum creatinine \> 1.5mg/dl)
- Chronic active liver disease (AST and ALT \> 3 times normal)
- Fasting blood glucose \> 126 mg/dl
- Anti-coagulant therapy (warfarin/heparin)
Key Trial Info
Start Date :
December 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2014
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT01497106
Start Date
December 1 2011
End Date
November 1 2014
Last Update
November 26 2014
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905