Status:
COMPLETED
A Pharmacokinetic and Pharmacodynamic Study of Phenoxymethylpenicillin for Children
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
Aarhus University Hospital Skejby
Department of Microbiological Surveillance and Research, SSI.
Conditions:
Phenoxymethylpenicillin
Eligibility:
All Genders
Up to 10 years
Phase:
PHASE1
Brief Summary
The aim of this trial is to evaluate the pharmacokinetics and pharmacodynamics of penicillin V in non-infectious children to estimate the optimum dosage regime in children.
Detailed Description
Although occasionally questioned, the efficacy of penicillin in eradication of respiratory tract infections in children has not been convincingly reported in the literature. Two randomized multicenter...
Eligibility Criteria
Inclusion
- Non-infectious Danish children at age 0-10 years who were admitted for a chromium51EDTA clearance test
Exclusion
- Children with allergy to penicillin and children with a prior known reduced glomerular filtration rate
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2013
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT01499875
Start Date
January 1 2012
End Date
August 1 2013
Last Update
October 1 2014
Active Locations (1)
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1
Department of Pediatrics, Århus University Hospital
Skejby, Aarhus, Denmark, 8200