Status:
COMPLETED
Effects of N-acetylcysteine on Low T3 Syndrome
Lead Sponsor:
Federal University of Rio Grande do Sul
Collaborating Sponsors:
Hospital de Clinicas de Porto Alegre
Programa de pós-graduação em endocrinologia
Conditions:
Acute Myocardial Infarction
Euthyroid Sick Syndrome
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
The propose of this study is to determine whether N-acetylcysteine is effective in reversing the changes in thyroid hormones seen in critical illness, known as the low T3 syndrome.
Detailed Description
The low T3 syndrome or nonthyroidal illness is characterized by low levels of T3, normal or high normal levels of rT3, low or normal levels of T4 and inappropriately normal or low levels of TSH. These...
Eligibility Criteria
Inclusion
- diagnosis of acute myocardial infarction with less than 12 hours of evolution
- reperfusion therapy (primary angioplasty)
Exclusion
- Thyroid disease
- Chronic renal disease with renal replacement therapy
- hepatic insufficiency
- immunosuppression
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
83 Patients enrolled
Trial Details
Trial ID
NCT01501110
Start Date
November 1 2011
End Date
November 1 2013
Last Update
March 31 2015
Active Locations (2)
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1
Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil, 90540001
2
Instituto de Cardiologia
Porto Alegre, Rio Grande do Sul, Brazil, 90540001