Status:
COMPLETED
Efficacy and Safety Study of Avastin to Treat Neovascularisation of the Cornea
Lead Sponsor:
University Hospital, Limoges
Conditions:
Corneal Newvessels
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Corneal newvessels may arise from a fan of pathologies, inducing long-standing corneal opacification requiring keratoplasty. These last years, VEGF inhibitors have been designed to reduce newasculariz...
Detailed Description
This study will involve 42 outpatients of the CHU of Limoges, Bordeaux, and Toulouse, addressed for corneal pathologies including corneal newvessels. The patients will be randomly assigned to two grou...
Eligibility Criteria
Inclusion
- inclusion criteria:
- Patients with corneal neovascularization whatever the origin
- Patient did not receive treatment with topical corticosteroids during the month preceding inclusion.
- Patient who has been properly informed and signed consent
- Patient aged over 18
- Patient affiliated with a health insurance plan or benefit of such a regime
Exclusion
- Patients who received local or general treatment of concomitant prostaglandin derivatives
- Patients with current infection of the cornea or other tissue / organ
- Women of childbearing age without contraception
- Pregnancy and Lactation
- Patient participating in another study
- Patient with contact lenses
- Patients with uncontrolled hypertension
- Patient with a history of stroke, myocardial infarction, angina pectoris, thrombophlebitis, Raynaud's phenomenon.
- Patients hypersensitive to the active substance or any excipients
- Patients hypersensitive to products of Chinese hamster ovary cells or other recombinant human or humanized antibodies.
- Patients with active bacterial eye infections, fungal, parasitic or viral infection (with the exception of herpes)
Key Trial Info
Start Date :
May 13 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2019
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT01501760
Start Date
May 13 2012
End Date
October 1 2019
Last Update
October 24 2019
Active Locations (5)
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1
Service d'Ophtalmologie
Limoges, France, 87042
2
CHU Poitiers-Ophtalmologie
Poitiers, France, 86021
3
CHU St Etienne
Saint-Etienne, France
4
CHU Strasbourg- Service Ophtalmlogie
Strasbourg, France, 67000