Status:
UNKNOWN
Efficacy of Ascorbic Acid for Prevention of Colistin-Associated Nephrotoxicity
Lead Sponsor:
Mahidol University
Collaborating Sponsors:
Siriraj Hospital
Conditions:
Drug Safety
Eligibility:
All Genders
18-80 years
Phase:
PHASE3
Brief Summary
Ascorbic acid (Vitamin C) could protect renal toxicity from colistin.
Detailed Description
Renal toxicity due to colistin therapy is common. Ascorbic acid (vitamin C) has been shown to prevent colistin associated renal toxicity in animals. This study is conducted to determine if acorbic aci...
Eligibility Criteria
Inclusion
- age \> 18 years hospitalized patient who needs colistin for therapy of nosocomial infection
Exclusion
- pregnant woman
- lactating mother
- allergy to ascorbic acid
- receiving non-steroidal antiinflammatory drugs (NSAID), aminoglycosides, vancomycin, cisplatin, amphotericin-B
- received radiocontrast media within 1 week
- renal stone
- G-6-PD deficiency
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2013
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT01501968
Start Date
January 1 2012
End Date
December 1 2013
Last Update
December 30 2011
Active Locations (1)
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1
Siriraj Hospital
Bangkok, Bangkok, Thailand, 10700