Status:
UNKNOWN
Intercalated Administration of PamCis With Gefitinib or Placebo as First Line Lung Adenocarcinoma in Never Smokers
Lead Sponsor:
National Cancer Center, Korea
Collaborating Sponsors:
AstraZeneca
Conditions:
Non Small Cell Lung Cancer
Adenocarcinoma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Intercalated administration of Iressa® (gefitinib) on days 5-18 of chemotherapy cycle improve the efficacy of Pemetrexed/platinum regimen given as first-line treatment for never-smokers with advanced ...
Detailed Description
Investigators believe this PFS curve crossing-over in both IPASS and First-SIGNAL study is mainly due to early progression of EGFR mutation-negative tumors after gefitinib alone. Taken together with t...
Eligibility Criteria
Inclusion
- Histologically or cytologically confirmed diagnosis of adenocarcinoma of lung with or without BAC features; however, adenocarcinoma combined with other histology, such as small cell carcinoma or squamous carcinoma, is not allowed.
- Stage IIIB (not amenable for radical loco-regional therapy) or stage IV (metastatic) patients according to the 7th TNM staging system
- Age 18-75
- Never-smoking defined as not more than 100 cigarettes during the lifetime
- ECOG performance status of 0-2
- Good organ function
- The presence of CNS metastases is not considered as an exclusion criterion, provided that there is good control of the symptoms with corticosteroids
- Patients must sign an informed consent indicating that they are aware of the investigational nature of the study in keeping with the policy of the hospital. The only approved consent form is attached to this protocol
Exclusion
- Patients with prior exposure to agents directed at the HER
- Patients with prior chemotherapy or therapy with systemic anti-tumour therapy for advanced disease.
- Lack of physical integrity of the upper gastrointestinal tract, or malabsorption syndrome, or inability to take oral medication, or have active peptic ulcer disease.
- Known severe hypersensitivity to gefitinib or to any of the study drugs.
- Any evidence of clinically active interstitial lung disease
- Concomitant use of phenytoin, carbamazepine, rifampicin, barbiturates, or St John's Wort
- Prior invasive malignancies 3 years prior to study entry except adequately treated cutaneous basal cell carcinoma or uterine cervix in situ cancer
- As judged by the investigator, any evidence of severe or uncontrolled systemic disease
- Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the subject to participate in the study
- Treatment with a non-approved or investigational drug within 30 days before Day 1 of study treatment.
- Pregnancy or breast-feeding (women of child-bearing potential).
- Sexually active males and females (of childbearing potential) unwilling to practice acceptable methods of birth control
Key Trial Info
Start Date :
March 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2015
Estimated Enrollment :
162 Patients enrolled
Trial Details
Trial ID
NCT01502202
Start Date
March 1 2012
End Date
February 1 2015
Last Update
June 20 2012
Active Locations (1)
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1
National Cancer Center
Goyang-si, Gyenggido, South Korea, 410-769