Status:
COMPLETED
Endophenotyping With Functional Magnetic Resonance Imaging (fMRI)
Lead Sponsor:
Charite University, Berlin, Germany
Collaborating Sponsors:
Central Institute of Mental Health, Mannheim
University Hospital, Bonn
Conditions:
Alcohol Dependence
Eligibility:
All Genders
18-75 years
Brief Summary
The mesolimbic dopaminergic reward system is a key structure underlying addictive behaviour in alcohol addiction and is under control of prefrontal glutamatergic neurotransmission. The aim of the pres...
Detailed Description
Alcohol addiction is one of the most common neuropsychiatric diseases in today's society. Chronic misuse of alcohol not only causes significant physical and psychological damage in afflicted individua...
Eligibility Criteria
Inclusion
- Healthy Controls
- men and women, aged 18 to 75
- legally effective, written informed consent for participation within the study
- right handedness
- no psychiatric disorder according to ICD 10
- no psychotropic substances within the last 7 days Alcohol-dependent patients
- men and women, aged 18 to 75
- legally effective, written informed consent for participation within the study
- right handedness
- no other psychiatric disorder according to ICD 10
- no psychotropic substances within the last 7 days
Exclusion
- physical disorders, which might interfere with the planned examination (e.g. cerebral or organic disorder)
- MR-contraindication (z.B. pace maker, metalic or electronic implants, metal splinters, operation clips)
- anamnestic manifest psychiatric axis I disorder and/or axis II according to ICD-10 except alcohol dependence for patients
- medication or drug dependence
- medication or drug abuse (randomized urin testing)
- insufficient knowledge of German language
- claustrophobia
- for women: pregnancy (exclusion via pregnancy test)
Key Trial Info
Start Date :
June 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2013
Estimated Enrollment :
480 Patients enrolled
Trial Details
Trial ID
NCT01503931
Start Date
June 1 2008
End Date
June 1 2013
Last Update
January 28 2016
Active Locations (1)
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1
Dept. of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin
Berlin, State of Berlin, Germany, 10117