Status:
UNKNOWN
The Impact of Targeted Therapy on Microorganism in Patients With Psoriasis
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Psoriasis
Eligibility:
All Genders
20-90 years
Brief Summary
Background: Psoriasis is a chronic, immunologically-mediated, inflammatory skin disease and targeted therapies e.g. tumor necrosis factor (TNF)-α and TH-17 antagonists have become increasing importan...
Detailed Description
Introduction As numerous studies have identified TNF-α, TH-17 and IL-17 as particularly major roles governing the inflammatory cascade in psoriasis, target therapies, including TNF-α and TH-17 antagon...
Eligibility Criteria
Inclusion
- Study 1
- Clinical diagnosis of psoriasis/psoriatic arthritis and are going o receive target therapies in the near future
- Age more than 20 years old
- Will receive target therapies for psoriasis/psoriatic arthritis
- Willing to receive blood, hair and skin scale sampling
Exclusion
- Pregnancy
- Not candidates for topical therapies, such as :
- Active tuberculosis or HIV, human papillomaviruses, cytomegalovirus infection, Epstein-Barr virus infection Evidence of latent tuberculosis but refuse to receive isoniazid prophylaxis Have malignancy required for chemotherapy or radiotherapy Active uncontrolled hepatitis -Have received phototherapy, systemic immunosuppressants or target therapies within 14, 30, 84 days prior to enrollment, respectively Study 2 (case group)
- Inclusion Criteria:
- Clinical diagnosis of psoriasis/psoriatic arthritis
- Age more than years old
- Have received target therapies for more than 3 months
- willing to receive blood, hair and skin scale sampling
Key Trial Info
Start Date :
July 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2015
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01504113
Start Date
July 1 2011
End Date
June 1 2015
Last Update
January 5 2012
Active Locations (1)
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1
National Taiwan University Dermatology department
Taipei, Taiwan, 100